A29100

SMB Biocompatible (PEEK, Ceramic) system for continuous chromatography in the Laboratory scale

The AZURA Lab SMB A29100 is optimized for the multicolumn separation of binary mixtures of small or biomolecules in gram-scale. It is a standard configuration of our AZURA Lab SMB having biocompatible MOC. It consists of seven 8-multiposition valves and four AZURA P 4.1S included in four Assistants ASM 2.2L. The high pressure range and the biocompatibility as well as the flexibility of the multiposition valves make this system the perfect solution for SMB chromatography.

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.

System and process control: A29800 (one CORI-FLOW), A29801 (four CORI-FLOW)
Heating and column organisation: A29903 (oven), A29901 (column holder ID 50), A29902 (for columns with 8, 16 or 20mm ID)

A29101

SMB Stainless Steel system for continuous chromatography in the Laboratory scale

The AZURA Lab SMB A29101 system is optimized for the multicolumn separation of binary mixtures of small molecules in gram-scale. It is a standard configuration of our AZURA Lab SMB having stainless steel MOC. It consists of seven 8-multiposition valves and four AZURA P 4.1S included in four Assistants ASM 2.2L. The high pressure range as well as the flexibility of the multiposition valves make this system the perfect solution for SMB chromatography.

Available Upgrade-Kits

With our preconfigured Upgrade-Kits you can upgrade your SMB chromatography system very easily and build up the system you need.

System and process control: A29800 (one CORI-FLOW), A29801 (four CORI-FLOW)
Heating and column organisation: A29903 (oven), A29901 (column holder ID 50), A29902 (for columns with 8, 16 or 20mm ID)

A29201

SMB Pilot system for continuous purification

To extract high-purity pharmaceutical active ingredients from natural products at high yields is a major challenge. Simulated Moving Bed (SMB) chromatography, as a continuous LC method, sets the standard for productivity, purity and yield.

This AZURA SMB pilot system is dedicated for the continuous production of API´s. The System allows the continuous separation of mixtures of substances and extraction into two fractions. High purities and simultaneous yields of up to 100% distinguish this process from conventional preparative LC methods.

The system features four preparative Pump 2.1L and seven multi-position valves integrated into four AZURA Assistants ASM 2.2L

• The three system pumps are equipped with 500 ml/min stainless steel pump heads, enabling volume flows of up to 250 ml/min inside the SMB cycle. The feed pump works with a 100 ml pump head and can thus also precisely dose the feed in the low flow range.
• The seven multi-position valves, operated by the valve unifier VU 4.1, are made of stainless steel and are equipped with connections for 1/8" capillaries. The Valve Unifier VU 4.1, integrated in the ASM 2.2L provides the latest technology to our SMB systems. The smart valve drive features automatic valve recognition and adjusts torque and switching speed specifically for each valve. This RFID technology enables to read GLP data, for example the maintenance of the rotor seal exchange is simplified by automatic notifications.
• The new plug-in design of the ASM 2.2L allows the modules to be removed by loosening just four screws, enabling the user to quickly exchange the modules. Especially in production processes the downtime of a system in case of service has to be minimum.
• The PurityChrom® MCC control software provides an intuitive and easy operation of the SMB. PurityChrom® MCC offers the possibility to independently record, store, monitor, and process error messages, warnings of level meter as well as several detector signals (UV, RI), flowmeters and other signals via analog inputs. The software complies with 21 CFR Part 11.
• The Pilot SMB system includes four flowmeters. The flow rate accuracy in all SMB zones and the feed stream is recorded for each cycle. The use of four flowmeters allows a complete real-time monitoring of the entire SMB process so that the user can directly react to any deviations in the flow rates.
• As a complete system, the AZURA SMB pilot system will be pre-installed on a table with the dimensions 1300 x 870 x 1000 mm (WxDxH). Every device and capillaries are fixed and therefore well structured. Additional components i.e. flowmeters are also integrable. The product streams and the column in and outlets are placed user friendly outside the table ensuring a fast and easy connection via tube fittings. The easy cleanable stainless-steel surface, antistatic wheels and leakage tubs fulfils main requirements for production areas. The AZURA SMB Pilot System can be easily transferred by the customer inside or between different production sides due to its moveable design.

A29201

Cannabis Producer: SMB Pilot system for continuous cannabinoid production.

To extract high-purity pharmaceutical active ingredients from natural products at high yields is a major challenge. This also applies to the cannabinoid sector. Simulated Moving Bed (SMB) chromatography, as a continuous LC method, sets the standard for productivity, purity and yield.

This AZURA SMB pilot system "Cannabis Producer" is dedicated for the continuous production of cannabinoids from cannabis. The Cannabis Producer allows the continuous separation of mixtures of substances and extraction into two fractions. High purities and simultaneous yields of up to 100% distinguish this process from conventional preparative LC methods.

The system features four preparative Pump 2.1L and seven multi-position valves integrated into four AZURA Assistants ASM 2.2L

• The three system pumps are equipped with 500 ml/min stainless steel pump heads, enabling volume flows of up to 250 ml/min inside the SMB cycle. The feed pump works with a 100 ml pump head and can thus also precisely dose the feed in the low flow range.
• The seven multi-position valves, operated by the valve unifier VU 4.1, are made of stainless steel and are equipped with connections for 1/8" capillaries. The Valve Unifier VU 4.1, integrated in the ASM 2.2L provides the latest technology to our SMB systems. The smart valve drive features automatic valve recognition and adjusts torque and switching speed specifically for each valve. This RFID technology enables to read GLP data, for example the maintenance of the rotor seal exchange is simplified by automatic notifications.
• The new plug-in design of the ASM 2.2L allows the modules to be removed by loosening just four screws, enabling the user to quickly exchange the modules. Especially in production processes the downtime of a system in case of service has to be minimum.
• The PurityChrom® MCC control software provides an intuitive and easy operating of the SMB. PurityChrom® MCC offers the possibility to independently record, store, monitor, and process error messages, warnings of level meter as well as several detector signals (UV, RI), flowmeters and other signals via analog inputs. The software complies with 21 CFR Part 11.
• The Pilot SMB system includes four flowmeters. Flow rate accuracy in all SMB zones and the feed stream is recorded for each cycle. The use of four flowmeters allows a complete real-time monitoring of the entire SMB process so that the user can directly react to deviations of the flow rates.
• As a complete system, the Cannabis Producer will be pre-installed on a table with the dimensions 1300 x 870 x 1000 mm (WxDxH). Every device and capillaries are fixed and therefor well structured. Additional components i.e. flowmeters are also integrable. The product streams and the column in and outlets are placed user friendly outside the table ensuring a fast and easy connection via tube fittings. The easy cleanable stainless-steel surface, antistatic wheels and leakage tubs fulfils main requirements for production areas. The AZURA SMB Pilot System can be easily transferred by the customer inside or between different production sides due to the moveable design.